Estrosmart Plus formula contains vitex and zinc which help to regulate the menstrual cycle. Since vitex helps regulate ovulation it improves fertility. Estrosmart Plus helps control severe PMS and eliminates hormonal acne. This product also helps maintain healthy estrogen-to-progesterone balance in the body. Estrosmart Plus contains D-glucarate, indole-3-carbinol, decaffeinated green tea extract, vitex, curcumin, diindolylmethane, rosemary extract, zinc and sulforaphane.